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How is HGH produced?

Growth hormone is controlled by two processes, synthesis and secretion, which don’t coincide. HGH synthesis in the pituitary is a permanent process which continues the whole day on the same level when its secretion has the pulsatile nature. Secretion of growth hormone is regulated by 2 hormones, somatoliberin and somatostatin, which have opposite natures. The first one deliberates HGH, while the second hormone blocks the deliberation. During the day, their balance changes, and GH is secreted into the bloodstream.

Both somatostatin and somatoliberin are secreted by the hypothalamus and bound to receptors of somatotropic cells in the pituitary, thus regulating HGH secretion.